Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). The dosage is based on your medical condition, age, weight, kidney function, response to treatment, and other medications you may be taking. If you cannot swallow the tablet whole, you may crush the tablet and mix with water, apple juice, or applesauce and take it right away. Take this medication by mouth with or without food as directed by your doctor, usually twice daily (every 12 hours). If you have any questions, ask your doctor or pharmacist.

Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start taking apixaban and each time you get a refill. Tell your doctor right away if you notice symptoms such as back pain, leg numbness/tingling/weakness, loss of control of the bowels or bladder ( incontinence). The risk of bleeding may be higher if you have a deformed spine, or have had spinal procedures/surgery before (such as epidural catheter placement, difficult epidural/spinal puncture), or are taking other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, ' blood thinners' such as warfarin/ enoxaparin, nonsteroidal anti-inflammatory drugs- NSAIDs such as ibuprofen). Ask your doctor about the benefits and risks before any spinal procedure. Bleeding in this area can cause paralysis that lasts a long time or could become permanent. People taking this medication may bleed near the spinal cord after certain spinal procedures.

Get medical help right away if you have weakness on one side of the body, trouble speaking, sudden vision changes, confusion, chest pain, trouble breathing, pain/warmth/swelling in the legs.

Your doctor may direct you to take a different 'blood thinning' or antiplatelet medication to reduce your risk. If you stop taking this medication early, you have a higher risk of forming a serious blood clot (such as a stroke, blood clot in the legs/ lungs). Do not stop taking apixaban unless directed by your doctor.

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